rss4medics RSS Medical Health Feed View

At the forefront of medicine, Gene Therapy brings you the latest research into genetic and cell-based technologies to treat disease. It also publishes Progress & Prospects reviews and News and Commentary articles, which highlight the cutting edge of the field.

Second-generation HIF-activated oncolytic adenoviruses with improved replication, oncolytic, and antitumor efficacy 22 Jul 2010

Second-generation HIF-activated oncolytic adenoviruses with improved replication, oncolytic, and antitumor efficacy

Gene Therapy advance online publication, July 22, 2010. doi:10.1038/gt.2010.100

Authors: T Cherry, S L Longo, Z Tovar-Spinoza & D E Post

Naked DNA expressing two isoforms of hepatocyte growth factor induces collateral artery augmentation in a rabbit model of limb ischemia 29 Jul 2010

Naked DNA expressing two isoforms of hepatocyte growth factor induces collateral artery augmentation in a rabbit model of limb ischemia

Gene Therapy advance online publication, July 29, 2010. doi:10.1038/gt.2010.101

Authors: W-B Pyun, W Hahn, D-S Kim, W-S Yoo, S-D Lee, J-H Won, B-S Rho, Z-Y Park, J-M Kim & S Kim

Clearance and characterization of residual HSV DNA in recombinant adeno-associated virus produced by an HSV complementation system 29 Jul 2010

Clearance and characterization of residual HSV DNA in recombinant adeno-associated virus produced by an HSV complementation system

Gene Therapy advance online publication, July 29, 2010. doi:10.1038/gt.2010.102

Authors: G-J Ye, M M Scotti, J Liu, L Wang, D R Knop & G Veres

Mantle cell lymphoma salvage regimen: synergy between a reprogrammed oncolytic virus and two chemotherapeutics 5 Aug 2010

Mantle cell lymphoma salvage regimen: synergy between a reprogrammed oncolytic virus and two chemotherapeutics

Gene Therapy advance online publication, August 5, 2010. doi:10.1038/gt.2010.103

Authors: G Ungerechts, M E Frenzke, K-C Yaiw, T Miest, P B Johnston & R Cattaneo

The combination of immunosuppression and carrier cells significantly enhances the efficacy of oncolytic poxvirus in the pre-immunized host 12 Aug 2010

The combination of immunosuppression and carrier cells significantly enhances the efficacy of oncolytic poxvirus in the pre-immunized host

Gene Therapy advance online publication, August 12, 2010. doi:10.1038/gt.2010.104

Authors: Z S Guo, V Parimi, M E O'Malley, P Thirunavukarasu, M Sathaiah, F Austin & D L Bartlett

Robust cardiomyocyte-specific gene expression following systemic injection of AAV: in vivo gene delivery follows a Poisson distribution 12 Aug 2010

Robust cardiomyocyte-specific gene expression following systemic injection of AAV: in vivo gene delivery follows a Poisson distribution

Gene Therapy advance online publication, August 12, 2010. doi:10.1038/gt.2010.105

Authors: K-M R Prasad, Y Xu, Z Yang, S T Acton & B A French

Efficient delivery of DNA vaccines using human papillomavirus pseudovirions 29 Jul 2010

Efficient delivery of DNA vaccines using human papillomavirus pseudovirions

Gene Therapy advance online publication, July 29, 2010. doi:10.1038/gt.2010.106

Authors: S Peng, A Monie, T H Kang, C-F Hung, R Roden & T-C Wu

Combinatorial gene therapy induces regression of hepatic encephalopathy 12 Aug 2010

Combinatorial gene therapy induces regression of hepatic encephalopathy

Gene Therapy advance online publication, August 12, 2010. doi:10.1038/gt.2010.107

Authors: F J Gálvez-Gastélum, J J Garcia-Bañuelos, C Beas-Zárate, A Segura-Flores, H González, V Chaparro-Huerta, A Salazar-Montes, A S Sandoval-Rodriguez, M Bueno-Topete, S Lucano-Landeros, D Medina-Preciado, I Gonzalez-Garcia & J Armendáriz-Borunda

Hydrostatic isolated limb perfusion with adeno-associated virus vectors enhances correction of skeletal muscle in Pompe disease 5 Aug 2010

Hydrostatic isolated limb perfusion with adeno-associated virus vectors enhances correction of skeletal muscle in Pompe disease

Gene Therapy advance online publication, August 5, 2010. doi:10.1038/gt.2010.109

Authors: B Sun, S Li, A Bird & D D Koeberl

Inhibition of the IKK/NF-κB pathway by AAV gene transfer improves muscle regeneration in older mdx mice 19 Aug 2010

Inhibition of the IKK/NF-κB pathway by AAV gene transfer improves muscle regeneration in older mdx mice

Gene Therapy advance online publication, August 19, 2010. doi:10.1038/gt.2010.110

Authors: Y Tang, D P Reay, M N Salay, M Y Mi, P R Clemens, D C Guttridge, P D Robbins, J Huard & B Wang

Gene therapy in the second eye of RPE65-deficient dogs improves retinal function 12 Aug 2010

Gene therapy in the second eye of RPE65-deficient dogs improves retinal function

Gene Therapy advance online publication, August 12, 2010. doi:10.1038/gt.2010.111

Authors: M J Annear, J T Bartoe, S E Barker, A J Smith, P G Curran, J W Bainbridge, R R Ali & S M Petersen-Jones

Targeting tumor gene by shRNA-expressing Salmonella-mediated RNAi 2 Sep 2010

Targeting tumor gene by shRNA-expressing Salmonella-mediated RNAi

Gene Therapy advance online publication, September 2, 2010. doi:10.1038/gt.2010.112

Authors: H Guo, J Zhang & C Inal

Systemic delivery of E6/7 siRNA using novel lipidic particles and its application with cisplatin in cervical cancer mouse models 12 Aug 2010

Systemic delivery of E6/7 siRNA using novel lipidic particles and its application with cisplatin in cervical cancer mouse models

Gene Therapy advance online publication, August 12, 2010. doi:10.1038/gt.2010.113

Authors: S Y Wu, A Singhania, M Burgess, L N Putral, C Kirkpatrick, N M Davies & N A J McMillan

E-cadherin contributes to the bystander effect of TK/GCV suicide therapy and enhances its antitumoral activity in pancreatic cancer models 19 Aug 2010

E-cadherin contributes to the bystander effect of TK/GCV suicide therapy and enhances its antitumoral activity in pancreatic cancer models

Gene Therapy advance online publication, August 19, 2010. doi:10.1038/gt.2010.114

Authors: L Garcia-Rodríguez, D Abate-Daga, A Rojas, J R González & C Fillat

Use of human MAR elements to improve retroviral vector production 2 Sep 2010

Use of human MAR elements to improve retroviral vector production

Gene Therapy advance online publication, September 2, 2010. doi:10.1038/gt.2010.115

Authors: M Buceta, J L Galbete, C Kostic, Y Arsenijevic & N Mermod

Non-viral S/MAR vectors replicate episomally in vivo when provided with a selective advantage 26 Aug 2010

Non-viral S/MAR vectors replicate episomally in vivo when provided with a selective advantage

Gene Therapy advance online publication, August 26, 2010. doi:10.1038/gt.2010.116

Authors: S P Wong, O Argyros, C Coutelle & R P Harbottle

Metabolically stabilized long-circulating PEGylated polyacridine peptide polyplexes mediate hydrodynamically stimulated gene expression in liver 19 Aug 2010

Metabolically stabilized long-circulating PEGylated polyacridine peptide polyplexes mediate hydrodynamically stimulated gene expression in liver

Gene Therapy advance online publication, August 19, 2010. doi:10.1038/gt.2010.117

Authors: C A Fernandez, N J Baumhover, J T Duskey, S Khargharia, K Kizzire, M D Ericson & K G Rice

Long-term, antidiabetogenic effects of GLP-1 gene therapy using a double-stranded, adeno-associated viral vector 19 Aug 2010

Long-term, antidiabetogenic effects of GLP-1 gene therapy using a double-stranded, adeno-associated viral vector

Gene Therapy advance online publication, August 19, 2010. doi:10.1038/gt.2010.119

Authors: S H Choi & H C Lee

Synergistic anti-tumor effects between oncolytic vaccinia virus and paclitaxel are mediated by the IFN response and HMGB1 26 Aug 2010

Synergistic anti-tumor effects between oncolytic vaccinia virus and paclitaxel are mediated by the IFN response and HMGB1

Gene Therapy advance online publication, August 26, 2010. doi:10.1038/gt.2010.121

Authors: B Huang, R Sikorski, D H Kirn & S H Thorne

Direct and long-term detection of gene doping in conventional blood samples 2 Sep 2010

Direct and long-term detection of gene doping in conventional blood samples

Gene Therapy advance online publication, September 2, 2010. doi:10.1038/gt.2010.122

Authors: T Beiter, M Zimmermann, A Fragasso, J Hudemann, A M Niess, M Bitzer, U M Lauer & P Simon

Preclinical correction of human Fanconi anemia complementation group A bone marrow cells using a safety-modified lentiviral vector 20 May 2010

Preclinical correction of human Fanconi anemia complementation group A bone marrow cells using a safety-modified lentiviral vector

Gene Therapy advance online publication, May 20, 2010. doi:10.1038/gt.2010.62

Authors: P S Becker, J A Taylor, G D Trobridge, X Zhao, B C Beard, S Chien, J Adair, D B Kohn, J E Wagner, A Shimamura & H-P Kiem

A probasin promoter, conditionally replicating adenovirus that expresses the sodium iodide symporter (NIS) for radiovirotherapy of prostate cancer 29 Apr 2010

A probasin promoter, conditionally replicating adenovirus that expresses the sodium iodide symporter (NIS) for radiovirotherapy of prostate cancer

Gene Therapy advance online publication, April 29, 2010. doi:10.1038/gt.2010.63

Authors: M A Trujillo, M J Oneal, S McDonough, R Qin & J C Morris

Cell-based osteoprotegerin therapy for debris-induced aseptic prosthetic loosening on a murine model 29 Apr 2010

Cell-based osteoprotegerin therapy for debris-induced aseptic prosthetic loosening on a murine model

Gene Therapy advance online publication, April 29, 2010. doi:10.1038/gt.2010.64

Authors: L Zhang, T-H Jia, A C M Chong, L Bai, H Yu, W Gong, P H Wooley & S-Y Yang

Ectopic matrix metalloproteinase-9 expression in human brain tumor cells enhances oncolytic HSV vector infection 13 May 2010

Ectopic matrix metalloproteinase-9 expression in human brain tumor cells enhances oncolytic HSV vector infection

Gene Therapy advance online publication, May 13, 2010. doi:10.1038/gt.2010.66

Authors: C-S Hong, W Fellows, A Niranjan, S Alber, S Watkins, J B Cohen, J C Glorioso & P Grandi

Local arterial nanoparticle delivery of siRNA for NOX2 knockdown to prevent restenosis in an atherosclerotic rat model 20 May 2010

Local arterial nanoparticle delivery of siRNA for NOX2 knockdown to prevent restenosis in an atherosclerotic rat model

Gene Therapy advance online publication, May 20, 2010. doi:10.1038/gt.2010.69

Authors: J M Li, P E Newburger, M J Gounis, P Dargon, X Zhang & L M Messina

BDNF regulation under GFAP promoter provides engineered astrocytes as a new approach for long-term protection in Huntington's disease 13 May 2010

BDNF regulation under GFAP promoter provides engineered astrocytes as a new approach for long-term protection in Huntington's disease

Gene Therapy advance online publication, May 13, 2010. doi:10.1038/gt.2010.71

Authors: A Giralt, H C Friedman, B Caneda-Ferrón, N Urbán, E Moreno, N Rubio, J Blanco, A Peterson, J M Canals & J Alberch

Adenoviral gene transfer of bone morphogenetic protein-7 enhances functional recovery after sciatic nerve injury in rats 3 Jun 2010

Adenoviral gene transfer of bone morphogenetic protein-7 enhances functional recovery after sciatic nerve injury in rats

Gene Therapy advance online publication, June 3, 2010. doi:10.1038/gt.2010.72

Authors: M-J Tsai, H-A Pan, D-Y Liou, C-F Weng, B J Hoffer & H Cheng

Signed outside: a surface marker system for transgenic cytoplasmic proteins 6 May 2010

Signed outside: a surface marker system for transgenic cytoplasmic proteins

Gene Therapy advance online publication, May 6, 2010. doi:10.1038/gt.2010.73

Authors: V Wohlgensinger, R Seger, M D Ryan, J Reichenbach & U Siler

Increased interstitial pressure improves nucleic acid delivery to skin enabling a comparative analysis of constitutive promoters 13 May 2010

Increased interstitial pressure improves nucleic acid delivery to skin enabling a comparative analysis of constitutive promoters

Gene Therapy advance online publication, May 13, 2010. doi:10.1038/gt.2010.74

Authors: E González-González, H Ra, R Spitler, R P Hickerson, C H Contag & R L Kaspar

Delivery of an EBV episome by a self-circularizing helper-dependent adenovirus: long-term transgene expression in immunocompetent mice 13 May 2010

Delivery of an EBV episome by a self-circularizing helper-dependent adenovirus: long-term transgene expression in immunocompetent mice

Gene Therapy advance online publication, May 13, 2010. doi:10.1038/gt.2010.75

Authors: J S Gil, S D Gallaher & A J Berk

Efficient inhibition of B-cell lymphoma xenografts with a novel recombinant fusion protein: anti-CD20Fab-LDM 13 May 2010

Efficient inhibition of B-cell lymphoma xenografts with a novel recombinant fusion protein: anti-CD20Fab-LDM

Gene Therapy advance online publication, May 13, 2010. doi:10.1038/gt.2010.76

Authors: C Xin, S Ye, Y Ming, Z Shenghua, M Qingfang, G Hongxing, S Xu, X Yuanfu, Z Yuan, F Dongmei, L Juanni, G Yingdai, J Lianfang, S Rongguang, Z Zhenping, W Jianxiang, C Tao, Y Chunzheng, X Dongsheng & Z Yongsu

Quantitative fine-tuning of photoreceptor cis-regulatory elements through affinity modulation of transcription factor binding sites 13 May 2010

Quantitative fine-tuning of photoreceptor cis-regulatory elements through affinity modulation of transcription factor binding sites

Gene Therapy advance online publication, May 13, 2010. doi:10.1038/gt.2010.77

Authors: J Lee, C A Myers, N Williams, M Abdelaziz & J C Corbo

Intra-articular lentivirus-mediated delivery of galectin-3 shRNA and galectin-1 gene ameliorates collagen-induced arthritis 3 Jun 2010

Intra-articular lentivirus-mediated delivery of galectin-3 shRNA and galectin-1 gene ameliorates collagen-induced arthritis

Gene Therapy advance online publication, June 3, 2010. doi:10.1038/gt.2010.78

Authors: C-R Wang, A-L Shiau, S-Y Chen, Z-S Cheng, Y-T Li, C-H Lee, Y-T Yo, C-W Lo, Y-S Lin, H-Y Juan, Y-L Chen & C-L Wu

Mifepristone increases gamma-retroviral infection efficiency by enhancing the integration of virus into the genome of infected cells 20 May 2010

Mifepristone increases gamma-retroviral infection efficiency by enhancing the integration of virus into the genome of infected cells

Gene Therapy advance online publication, May 20, 2010. doi:10.1038/gt.2010.80

Authors: V Solodushko & B Fouty

Surface immobilization of hexa-histidine-tagged adeno-associated viral vectors for localized gene delivery 27 May 2010

Surface immobilization of hexa-histidine-tagged adeno-associated viral vectors for localized gene delivery

Gene Therapy advance online publication, May 27, 2010. doi:10.1038/gt.2010.81

Authors: J-H Jang, J T Koerber, K Gujraty, S R Bethi, R S Kane & D V Schaffer

Progress and prospects: graft-versus-host disease 27 May 2010

Progress and prospects: graft-versus-host disease

Gene Therapy advance online publication, May 27, 2010. doi:10.1038/gt.2010.83

Authors: S Mastaglio, M T L Stanghellini, C Bordignon, A Bondanza, F Ciceri & C Bonini

Improvement of the mdx mouse dystrophic phenotype by systemic in utero AAV8 delivery of a minidystrophin gene 10 Jun 2010

Improvement of the mdx mouse dystrophic phenotype by systemic in utero AAV8 delivery of a minidystrophin gene

Gene Therapy advance online publication, June 10, 2010. doi:10.1038/gt.2010.84

Authors: B M Koppanati, J Li, D P Reay, B Wang, M Daood, H Zheng, X Xiao, J F Watchko & P R Clemens

Regeneration of pancreatic islets in vivo by ultrasound-targeted gene therapy 27 May 2010

Regeneration of pancreatic islets in vivo by ultrasound-targeted gene therapy

Gene Therapy advance online publication, May 27, 2010. doi:10.1038/gt.2010.85

Authors: S Chen, M Shimoda, M-Y Wang, J Ding, H Noguchi, S Matsumoto & P A Grayburn

Ultrasound-assisted non-viral gene transfer to the salivary glands 27 May 2010

Ultrasound-assisted non-viral gene transfer to the salivary glands

Gene Therapy advance online publication, May 27, 2010. doi:10.1038/gt.2010.86

Authors: M J Passineau, L Zourelias, L Machen, P C Edwards & R L Benza

Efficient delivery of liposome-mediated MGMT-siRNA reinforces the cytotoxity of temozolomide in GBM-initiating cells 3 Jun 2010

Efficient delivery of liposome-mediated MGMT-siRNA reinforces the cytotoxity of temozolomide in GBM-initiating cells

Gene Therapy advance online publication, June 3, 2010. doi:10.1038/gt.2010.88

Authors: T Kato, A Natsume, H Toda, H Iwamizu, T Sugita, R Hachisu, R Watanabe, K Yuki, K Motomura, K Bankiewicz & T Wakabayashi

CFTR expression and activity from the human CFTR locus in BAC vectors, with regulatory regions, isolated by a single-step procedure 10 Jun 2010

CFTR expression and activity from the human CFTR locus in BAC vectors, with regulatory regions, isolated by a single-step procedure

Gene Therapy advance online publication, June 10, 2010. doi:10.1038/gt.2010.89

Authors: C Auriche, E G Di Domenico, S Pierandrei, M Lucarelli, S Castellani, M Conese, R Melani, O Zegarra-Moran & F Ascenzioni

MVA-nef induces HIV-1-specific polyfunctional and proliferative T-cell responses revealed by the combination of short- and long-term immune assays 10 Jun 2010

MVA-nef induces HIV-1-specific polyfunctional and proliferative T-cell responses revealed by the combination of short- and long-term immune assays

Gene Therapy advance online publication, June 10, 2010. doi:10.1038/gt.2010.90

Authors: S Kutscher, S Allgayer, C J Dembek, J R Bogner, U Protzer, F D Goebel, V Erfle & A Cosma

Adoptive immunotherapy with genetically engineered T cells: modification of the IgG1 Fc 'spacer' domain in the extracellular moiety of chimeric antigen receptors avoids 'off-target' activation and unintended initiation of an innate immune response 17 Jun 2010

Adoptive immunotherapy with genetically engineered T cells: modification of the IgG1 Fc ‘spacer’ domain in the extracellular moiety of chimeric antigen receptors avoids ‘off-target’ activation and unintended initiation of an innate immune response

Gene Therapy advance online publication, June 17, 2010. doi:10.1038/gt.2010.91

Authors: A Hombach, A A Hombach & H Abken

Addition of adenoviral vector targeting of chemotherapy to the MUC-1/ecdCD40L VPPP vector prime protein boost vaccine prolongs survival of mice carrying growing subcutaneous deposits of Lewis lung cancer cells 1 Jul 2010

Addition of adenoviral vector targeting of chemotherapy to the MUC-1/ecdCD40L VPPP vector prime protein boost vaccine prolongs survival of mice carrying growing subcutaneous deposits of Lewis lung cancer cells

Gene Therapy advance online publication, July 1, 2010. doi:10.1038/gt.2010.93

Authors: H Akbulut, Y Tang, K G Akbulut, J Maynard & A Deisseroth

Soluble TNF-α receptor secretion from healthy or dystrophic mice after AAV6-mediated muscle gene transfer 1 Jul 2010

Soluble TNF-α receptor secretion from healthy or dystrophic mice after AAV6-mediated muscle gene transfer

Gene Therapy advance online publication, July 1, 2010. doi:10.1038/gt.2010.94

Authors: G Moulay, C Masurier, P Bigey, D Scherman & A Kichler

Progress and prospects: Foamy virus vectors enter a new age 15 Jul 2010

Progress and prospects: Foamy virus vectors enter a new age

Gene Therapy advance online publication, July 15, 2010. doi:10.1038/gt.2010.95

Authors: O Erlwein & M O McClure

Carving the CAR 29 Jul 2010

Carving the CAR

Gene Therapy advance online publication, July 29, 2010. doi:10.1038/gt.2010.96

Authors: S R Riddell & U Protzer

Identification and removal of colanic acid from plasmid DNA preparations: implications for gene therapy 22 Jul 2010

Identification and removal of colanic acid from plasmid DNA preparations: implications for gene therapy

Gene Therapy advance online publication, July 22, 2010. doi:10.1038/gt.2010.97

Authors: P Firozi, W Zhang, L Chen, F A Quiocho, K C Worley & N S Templeton

Winners and losers and oncolytic adenoviruses: who should be down in the mouth? 29 Jul 2010

Winners and losers and oncolytic adenoviruses: who should be down in the mouth?

Gene Therapy advance online publication, July 29, 2010. doi:10.1038/gt.2010.98

Author: K J Harrington

Comparison of oncolytic adenoviruses for selective eradication of oral cancer and pre-cancerous lesions 5 Aug 2010

Comparison of oncolytic adenoviruses for selective eradication of oral cancer and pre-cancerous lesions

Gene Therapy advance online publication, August 5, 2010. doi:10.1038/gt.2010.99

Authors: H J T van Zeeburg, A Huizenga, A Brink, P B van den Doel, Z B Zhu, F McCormick, R H Brakenhoff & V W van Beusechem

Gene Therapy - AOP - nature.com science feeds